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Chest/Heartburn not responding to anti-acidity medications. Long standing hyperacidity (to detect Helicobacter Pylori infection ). Severe nausea/recurrent vomiting. Upper abdominal (epigastric ) pain. Difficulty in swallowing (Dysphagia,odynophagia). Feeling of indigestion/Gas bloat/Excessive flatulence. Unexplained weight loss. Chronic anaemia. Chronic diarrhoea. Unexplained chronic cough. Hematemesis or malena (black stools). Diagnosis of early esophageal/stomach cancer. Endoscopic extraction of accidentally swallowed